cTnI/CK-MB/Myo (Cardiac Troponin I/MB Isoenzyme of Creatine Kinase/Myoglobin) Detection Kit

• INTENDED USE

The cTnI/CK-MB/Myo (Cardiac Troponin I/MB Isoenzyme of Creatine Kinase/Myoglobin) Detection Kit (Fluorescence Immunochromatography) is used for the quantitative determination of cardiac Troponin I (cTnI), Creatine Kinase-MB (CK-MB) and Myoglobin(Myo) in human serum and plasma in vitro. For professional in vitro diagnostic use only, not for personal use.

• CLINICAL SIGNIFICANCE

Cardiac Troponin I (cTn I) is a cardiac muscle protein with a molecular weight of 22.5 kilodaltons. Together with Troponin T (Tn T) and Troponin C (Tn C), Tn forms a Troponin complex in heart to play a fundamental role in the transmission of intracellular calcium signal actin-myosin interaction. Troponin I prevents myosin from binging to actin in relaxed muscle. When calcium binds to troponin C, a conformational change occurs and causes dislocation of troponin I. cTnl or the cardiac troponin I is usually used to identify individuals who have experienced damage to the heart. The concentration of cTnl is normally low in the blood, but is released when damage occurs in the heart muscle cells. A higher concentration of cTnl in the blood can indicate bigger damage in the heart. Therefore, cTn I is a specific marker for diagnosis of AMI.

Creatine Kinase Isoenzymes MB (CK-MB) is one of the three isoenzymes of creatine kinase. CK-MB is mainly present in the myocardium, and other tissues are almost non-existent. Clinically Isozyme (CK-MB) is considered to be a specific and sensitive indicator of myocardial injury, and Its total activity ratio with CK can be used as a basis for diagnosis of acute myocardial infarction.

Myoglobin is an oxygen-binding heme protein, and mainly distributed in myocardium and skeletal muscle tissue. In acute myocardial injury, myoglobin is first released into the blood. After about 2-3 hours of symptoms, myoglobin in the blood can exceed the upper limit of normal, peaking at 9-12 hours, and returning to normal after 24-36 hours. Determination of serum myoglobin is as the early and most sensitive indicator of acute myocardial infarction (AMI) diagnosis.

• PRODUCT SPECIFICATION

Specimen: Plasma/Serum

Reaction Time: 15 min

Detection Range: cTnI: 0.1-40ng/mL, CK-MB:1-100ng/mL, Myo:5-400ng/mL

Storage Temperature: 4-30℃

Qualification: CE

• APPLICATION DEPARTMENT

Laboratory Department, Emergency Department, ICU, Cardiology Department, Outpatient clinic, Physical Examination Center, other Departments, etc.